Prior to joining the University of Utah
Postdoc work
11. Wang, Y.*, Zhang, L., Dai, Q., Ye, C., Zhang, W., Cui, X., Wang, K., Luo, M., Pan, T., and He, C*. Enzyme-assisted alkynylation enables transcriptome-wide identification of pseudouridine modifications. (* denotes co-correspondence) bioRxiv, doi: https://doi.org/10.1101/2023.06.18.545436
10. Hu, L.; Liu, S.; Peng, Y.; Ge, R.; Su, R.; Senevirathne, C.; Harada, B.T.; Dai, Q.; Wei, J.; Zhang, L.; Hao, Z.; Luo, L.; Wang, H.; Wang, Y.; Luo, M.; Chen, M.; Chen, J.; and He, C (2022). Quantitative RNA m6A Sequencing Reveals Dynamic Human Epitranscriptome. Nat. Biotech., 40(8):1210-1219.
9. Dai, Q.; Zhang, L.; Sun, H.; Pajdzik, K.; Yang, L.; Ye, C.; Ju, C.; Liu, S.; Wang, Y.; Zheng, Z.; Zhang, L.; Harada, B.; Irkliyenko, I.; Zhang, W.; Pan, T.; and He, C (2022). Quantitative sequencing uncovers abundant pseudouridines in mammalian mRNA at base resolution. Nat. Biotech., 41, 344-354.
8. Zhang, L., Xiong, Q., Perez, S., Liu, C., Wei, J., Le, C., Zhang, L., Harada, B.T., Dai, Q., Feng, X., Hao, Z., Wang, Y., Dong, X., Hu, L., Wang, E., Pan, T., Klungland, A., Liu, R., and He, C. (2021) ALKBH7-mediated demethylation regulates mitochondiral polycistronic RNA processing. Nat. Cell Biol., 23, 684-691.
7. Wang, Y., Zhang, Z.,Sepich, C., Zhang, L., Xiao, Y., and He, C. (2020) LEAD-m6A-seq for locus-specific detection of N6-methyladenosine and quantification of differential methylation. Angew. Chem. Int. Ed., 60 (2), 873-880. Featured as hot paper.
6. Wang, Y., Katanski, C.D., Watkins, C., Pan, J.N., Dai, Q., Jiang, Z., and Pan, T. (2020) A high throughput screening method for evolving a demethylase enzyme with new functionalities. Nucleic Acids Res. DOI: 10.1093/nar/gkaa1213
Graduate work
5. Wang, Y., Chung, D., Monteleone, L.R., Li, J., Chiang, Y., Toney, M., and Beal, P.A. (2019) RNA Binding Candidates for Human ADAR3 from Substrates of a Gain of Function Mutant Expressed in Neuronal Cells. Nucleic Acids Res., 47(20), 10801-10814.
4. Wang, Y. Park, S. and Beal, P. A. (2018) Selective recognition of RNA substrates by ADAR deaminase domains. Biochemistry, 57(10),1640-1651.
3. Wang, Y., Zheng Y. and Beal, P.A. (2017) Adenosine Deaminases that Act on RNA (ADARs). The Enzymes, 41, 215-268.
2. Wang, Y. and Beal, P.A. (2016) Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. Nucleic Acids Res., 44(20), 9872-9880.
1.Wang, Y., Havel, J. and Beal, P.A. (2015) A phenotypic screen for functional mutants of human adenosine deaminase acting on RNA 1. ACS Chem. Biol., 10, 2512-2519.