Welcome to the RNA Lab!
Eukaryotic RNAs undergo a wide range of post-transcriptional modification. These RNA modifications encompass a wide array of chemical alterations, including methylation (e.g., N6-methyladenosine, m7G, m1A, Nm), deamination (e.g., I), acetylation (e.g., ac4C), and isomerization (e.g., Pseudouridine). Leveraging their unique chemical attributes, these modifications have the potential to regulate RNA properties and affect protein-RNA interactions. Aberrations in modification distribution or extent have been associated with cellular malfunctions and human diseases.
The Wang lab endeavors to understand where and how certain modifications are installed and what do they do to RNA functions. We are dedicated to pioneering novel assays, and studying the association of certain modifications with human diseases and their contributions to physiological activities, such as innate immunity and neuronal development. We aim to achieve a deeper understanding of the regulation of RNA modifications, and with these insights we aspire to propel the development of RNA therapeutics and the identification of novel drug targets.
Trainees in the Wang Lab will be exposed to various interdisciplinary techniques, including biochemistry, chemical biology, cell biology, protein engineering, and bioinformatics.
Contact Us
Room 1962, L.S. Skaggs Building
Lab phone: 801-646-8066
Department of Medicinal Chemistry
30 S 2000 E, Salt Lake City, UT, 84112
